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Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered during the last trimester of pregnancy and may precipitate premature parturition followed by dystociafetal deathretained placenta and metritis.

Frequency not reportedAcneallergic dermatitiscutaneous and subcutaneous atrophydry scaly skinecchymosispetechiaeerythemahyperpigmentationhypopigmentationimpaired wound healingincreased sweatingrashsterile abscessstriaesuppressed reactions to skin teststhin fragile skinthinning scalp hairurticariahypertrichosisangioedemaskin atrophyhyperhidrosispruritusRef]

Other Conditions In certain conditions where it is desired to reduce inflammationvascularizationfibroblastic infiltrationand scar tissuethe use of DEPO-MEDROL should be consideredSnakebite of dogs also is an indication for the use of this suspension because of its anti-toxemicanti-shockand anti-inflammatory activityIt is particularly effective in reducing swelling and preventing sloughingIts employment in the treatment of such conditions is recommended as a supportive measure to standard procedures and timehonored treatments and will give comfort to the animal and hasten complete recovery.

Frequency not reportedCushingoid statehirsutismsecondary adrenocortical and pituitary unresponsivenessparticularly in times of stressas in traumasurgeryor illnessmoon faceRef]

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