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Monoamine oxidase inhibitorsRizatriptan is principally metabolised via monoamine oxidaseAsubtypeMAO-APlasma concentrations of rizatriptan and its active N-monodesmethyl metabolite were increased by concomitant administration of a selectivereversible MAO-A inhibitorSimilar or greater effects are expected with non-selectivereversiblee.glinezolidand irreversible MAO inhibitorsDue to a risk of coronary artery vasoconstriction and hypertensive episodesadministration of MAXALT to patients taking inhibitors of MAO is contraindicatedsee section 4.3

Maxalt should not be used to treat a common tension headachea headache that causes loss of movement on one side of your bodyor any headache that seems to be different from your usual migraine headachesUse this medicine only if your condition has been confirmed by a doctor as migraine headaches.

A history of coronary artery diseaseanginachest painheart attackor strokeincludingmini-stroke

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Maxalt is characterized by a relatively quick onset of action aiming at reducing blood pressure by affecting the blood vessels located around the brain.

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You should not take this medication if you are allergic to rizatriptanif you have any history of heart diseaseor if you have coronary heart diseaseanginablood circulation problemslack of blood supply to the heartuncontrolled high blood pressureischemic bowel diseasea history of a heart attack or strokeor if your headache seems to be different from your usual migraine headaches.

PRECAUTIONSBefore using rizatriptantell your doctor or pharmacist if you are allergic to itor if you have any other allergiesThis product may contain inactive ingredientswhich can cause allergic reactions or other problemsTalk to your pharmacist for more details.Before using this medicationtell your doctor or pharmacist your medical historyespecially ofblood circulation problemsfor examplein your legsarms/handsor stomachcertain types of headacheshemiplegic or basilar migraineheart problemssuch as chest painirregular heartbeatprevious heart attackliver diseaseseizurestroke ormini-stroketransient ischemic attackCertain conditions can increase your risk for heart problemsTell your doctor if you have any of these conditionsincludinghigh blood pressurehigh cholesteroldiabetesfamily history of heart diseaseoverweightsmokerpostmenopausalwomenage more than 40 yearsmenThis drug may make you dizzy or drowsyDo not driveuse machineryor do any activity that requires alertness until you are sure you can perform such activities safelyLimit alcoholic beverages.Before having surgerytell your doctor or dentist about all the products you useincluding prescription drugsnonprescription drugsand herbal productsThe risk of heart diseaseliver diseaseand high blood pressure increases with ageOlder adults may be more sensitive to the side effects of this drugespecially increased blood pressure and heart problems.During pregnancythis medication should be used only when clearly neededDiscuss the risks and benefits with your doctor.It is unknown if this drug passes into breast milkConsult your doctor before breast-feeding.

If there is no improvement in your symptomsdo not take more doses of this medication before talking to your doctorIf your symptoms are only partly relievedor if your headache comes backadults may take another dose at least 2 hours after the first doseChildren should not take more than one doseor 5 milligrams in a 24-hour periodFor adultsthe US manufacturer recommends a maximum dose of 30 milligrams in a 24-hour periodThe Canadian manufacturer recommends a maximum dose of 20 milligramsfor adultsin a 24-hour period.

Because animal reproductive and developmental studies are not always predictive of human responseMAXALT should be used during pregnancy only if clearly needed.

Other 5-HT 1B/1D agonistse.gsumatriptanshould not be used concomitantly with MAXALTsee section 4.5

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some estimates suggest that upwards of 80 of individuals will have success with using maxalt as an abortive migraine therapy.

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