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DUse in LIFE-THREATENING emergencies when no safer drug availablePositive evidence of human fetal risk.

Follow all directions on your prescription labelDo not take this medicine in larger or smaller amounts or for longer than recommended.

Store at room temperature away from light and moistureDo not store in the bathroomKeep all medications away from children and pets.

Before using this medicationtell your doctor or pharmacist your medical historyespecially ofblood circulation problemsfor examplein your legsarms/handsor stomachcertain types of headacheshemiplegic or basilar migraineheart problemssuch as chest painirregular heartbeatprevious heart attackliver diseaseseizurestroke ormini-stroketransient ischemic attack

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Tell your doctor if you are taking buspirone buspar ; epinephrine epipen ; medications for migraine such as almotriptan axert , eletriptan relpax , frovatriptan frova , naratriptan amerge , rizatriptan maxalt , sumatriptan imitrex , and zolmitriptan zomig ; meperidine demerol ; pseudoephedrine sudafed; in many cold or decongestant medications selective serotonin reuptake inhibitors ssris such as citalopram celexa , escitalopram lexapro , fluoxetine prozac, sarafem, symbyax , fluvoxamine luvox , paroxetine paxil , sertraline zoloft , and vilazodone vilbyrd ; serotonin norepinephrine reuptake inhibitors snris such as desvenlafaxine pristiq , duloxetine cymbalta , and venlafaxine effexor ; and tricyclic antidepressants such as amitriptyline elavil , amoxapine asendin , clomipramine anafranil , desipramine norpramin , doxepin adapin, sinequan , imipramine tofranil , nortriptyline aventyl, pamelor , protriptyline vivactil , and trimipramine surmontil .

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This medication may increase serotonin and rarely cause a very serious condition called serotonin syndrome/toxicityThe risk increases if you are also taking other drugs that increase serotoninso tell your doctor or pharmacist of all the drugs you takesee Drug Interactions sectionGet medical help right away if you develop some of the following symptomsfast heartbeathallucinationsloss of coordinationsevere dizzinesssevere nausea/vomiting/diarrheatwitching musclesunexplained feverunusual agitation/restlessness.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effectsMany people using this medication do not have serious side effects.

In a drug interaction studynadolol and metoprolol did not alter plasma concentrations of rizatriptan.

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A condition for which you take propranololHemangeolInderalInnoPranor.

Concurrent administration of monoamine oxidaseMAOinhibitors or use within two weeks of discontinuation of MAO inhibitor therapysee section 4.5

Initial dose5 mg or 10 mg orallyonceProvided there has been a response to first dosea second dose may be administered at least 2 hours later if migraine returnsMaximum dose30 mg in a 24-hour period.

OVERDOSEIf overdose is suspectedcontact a poison control center or emergency room immediatelyUS residents can call their local poison control center at 1-800-222-1222Canada residents can call a provincial poison control center.

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