Patients with liver dysfunction should begin with a low dose of fluvoxamine maleate tablets and increase it slowly with careful monitoring.
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May be potentiated by cyp3a4 inhibitors substrates or cyp2d6 enzymes eg, itraconazole, nefazodone, buspirone, venlafaxine, alprazolam, fluvoxamine, quinidine, fluoxetine, sertraline, chlorpromazine, promethazine.
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after coadministration of fluvoxamine for 14 days, mean trough concentrations of clozaril and its metabolites, n -desmethylclozapine and clozaril n -oxide, were elevated about three-fold compared to baseline steady-state concentrations.
