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Increases in blood glucose and alterations in glucose tolerance testswith abnormalities of fasting and 2 hour postprandial sugarhave been observedand rarelyprecipitation of diabetes mellitus reported.

Efficacy is diminished and risk of ototoxicity increased in patients with hypoproteinemiaassociated with nephrotic syndromeototoxicity is associated with rapid injectionsevere renal impairmentuse of higher than recommended dosesconcomitant therapy with aminoglycoside antibioticsethacrynic acidor other ototoxic drugs.

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In premature infants LASIX may precipitate nephrocalcinosis/nephrolithiasistherefore renal function must be monitored and renal ultrasonography performedSee PRECAUTIONSPediatric Use

Phenytoin interferes directly with renal action of LASIXThere is evidence that treatment with phenytoin leads to decrease intestinal absorption of LASIXand consequently to lower peak serum furosemide concentrations.

Treatment during pregnancy requires monitoring of fetal growth because of the potential for higher birth weights.

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Methotrexate and other drugs thatlike LASIXundergo significant renal tubular secretion may reduce the effect of LASIXConverselyLASIX may decrease renal elimination of other drugs that undergo tubular secretionHigh-dose treatment of both LASIX and these other drugs may result in elevated serum levels of these drugs and may potentiate their toxicity as well as the toxicity of LASIX.

One study in six subjects demonstrated that the combination of furosemide and acetylsalicylic acid temporarily reduced creatinine clearance in patients with chronic renal insufficiencyThere are case reports of patients who developed increased BUNserum creatinine and serum potassium levelsand weight gain when furosemide was used in conjunction with NSAIDs.

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urine and blood glucose should be checked periodically in diabetics receiving lasix, even in those suspected of latent diabetes.