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Monitor for the following and reduce the dose or discontinue HYDREA accordingly:
To decrease the risk of contactadvise caregivers to wear disposable gloves when handling HYDREA or bottles containing HYDREAWash hands with soap and water before and after contact with the bottle or capsules when handling HYDREADo not open HYDREA capsulesAvoid exposure to crushed or opened capsulesIf contact with crushed or opened capsules occurs on the skinwash affected area immediately and thoroughly with soap and waterIf contact with crushed or opened capsules occurs on the eye(sthe affected area should be flushed thoroughly with water or isotonic eyewash designated for that purpose for at least 15 minutesIf the powder from the capsule is spilledimmediately wipe it up with a damp disposable towel and discard in a closed containersuch as a plastic bagas should the empty capsulesThe spill areas should then be cleaned three times using a detergent solution followed by clean waterKeep the medication away from children and petsContact your doctor for instructions on how to dispose of outdated capsules.
Wash hands before and after handling the medication or its containerYou and/or your caregiver should wear disposable gloves when handling this medication or its containerIf powder from the tablet or capsule spillswipe it up right away with a wet paper towel and throw away in a closed container such as a plastic bagClean the spill area right away with soap and waterMake sure not to breathe the powder from the tablets/capsules.
Examples of drugs that can cause interactions with hydroxyurea are listed below.
Three mechanisms of action have been postulated for the increased effectiveness of concomitant use of hydroxyurea therapy with irradiation on squamous cellepidermoidcarcinomas of the head and neckIn vitro studies utilizing Chinese hamster cells suggest that hydroxyurea1is lethal to normally radioresistant S-stage cellsand2holds other cells of the cell cycle in the G1 or pre-DNA synthesis stage where they are most susceptible to the effects of irradiationThe third mechanism of action has been theorized on the basis of in vitro studies of HeLa cellsIt appears that hydroxyureaby inhibition of DNA synthesishinders the normal repair process of cells damaged but not killed by irradiationthereby decreasing their survival rateRNA and protein syntheses have shown no alteration.
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dosage should be adjusted to reach remission of symptoms and treatment should continue for at least 6 to 12 months following last reported dysthymic experience purchase hydrea 500mg free shipping treatment centers, duration based on number of episodes.
