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The trochelozengeshould slowly dissolve in the mouthOne troche is administered 5 times daily for 14 daysClotrimazole creamlotionor solution is applied to the affected and surrounding skin areasgenerally twice daily in the morning and evening.

Clotrimazole is not administered systemicallyit is administered via oral/transmucosal lozengestrochestopicallyor intravaginallySmall amounts absorbed are metabolized in the liver and excreted in the bile.

The use of clotrimazole during breast-feeding has not been studiedTopical application is not expected to result in significant maternal absorptionand should not be of significant risk to a breast-feeding infantInstruct mothers not to apply clotrimazole topically to the breast during times of breast-feedingThe oral troches may be absorbed systemicallybut significant infant exposure is unknown and expected to be lowobserve the infant for any possible adverse effectsFluconazolemiconazoleand nystatin may be potential alternatives to considerthough site of infectionlocal susceptibility patternsand specific microbial susceptibility should be assessed before choosing an alternative agentConsider the benefits of breast-feedingthe risk of potential infant drug exposureand the risk of an untreated or inadequately treated conditionIf a breast-feeding infant experiences an adverse effect related to a maternally ingested or administered drughealth care providers are encouraged to report the adverse effect to the FDA.

There is little systemic absorption following clotrimazole topical application.

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