Excessive use of furosemide will result in dehydration or reduction in blood volume and may cause circulatory collapse and other related problems, particularly in older adults.

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The international non-proprietary name of Lasix is furosemideFurosemide is also the active substance of Lasix and belongs to the pharmacological group of loop diureticsThis pharmacological group aims to remove from the body an increased amount of water due to a decrease in the reabsorption of sodium and chloride in the special structure of the renal nephron-the loop of Henle.

Hypertension Thrombosis and Hemostasis Atherosclerosis Myocardial Infarction Ischemia/Reperfusion Injury Arrhythmias Heart Failure Request copy Download PDF.

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Multiple furosemide is used to reduce salt water in body and thus treat edema, heart failure or high bp.

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Overdose and treatment Signs and symptoms of overdose include profound electrolyte and volume depletionwhich may precipitate circulatory collapseTreatment is chiefly supportivereplace fluids and electrolytes.

Adverse reactions CNSvertigoheadachedizzinessparesthesiarestlessnessfeverCVvolume depletion and dehydrationorthostatic hypotensionthrombophlebitis with I.VadministrationEENTtransient deafness with too-rapid I.Vinjectionblurred visionGIabdominal discomfort and paindiarrheaanorexianauseavomitingconstipationPANCREATITISGUnocturiaazotemiapolyuriafrequent urinationrenal failureoliguriaHematologicagranulocytosisleukopeniathrombocytopeniaanemiaaplastic anemiaMetabolichypokalemiahypochloremic alkalosisasymptomatic hyperuricemiafluid and electrolyte imbalancesincluding dilutional hyponatremiahypocalcemiahypomagnesemiahyperglycemiaimpaired glucose toleranceMusculoskeletalmuscle spasmweaknessSkindermatitispurpuratransient pain at I.Minjection site.

Contraindications and precautions Contraindicated in patients hypersensitive to drug and patients with anuriahepatic comaor severe electrolyte depletionContraindicated if increased azotemiaoliguriaor progressive renal disease occur during therapyUse cautiously in pregnant womenpatients with sulfa allergyand in those with hepatic cirrhosis.

Lasix overdose results in rapid dehydrationThe BCC decreasesthe volume of circulating bloodand cardiac arrhythmias and/or blockades developBlood pressure also sharply dropsacute renal failure occursand consciousness is disturbed.

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concomitant use of furosemide and aspirin may, therefore, lead to high blood levels of aspirin and aspirin toxicity.

In preterm infants, most clients with renal impairment require diuretics as part furosemide stimulates production of prostaglandin e2 in the of their drug therapy regimens.

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Deeb et al2013Disrupted Clhomeostasis contributes to reductions in the inhibitory efficacy of diazepam during hyperexcited statesEur J Neurosci 38 2453 PMID23627375.

Furosemide is a diuretic that is used in anti-hypertensive therapy and for the relief of edema.

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in the united states it is available as a generic medication, furosemide is on the world anti-doping agencys banned drug list due to concerns that it may mask other drugs.