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In 2005the FDA approved Fosamax Plus Dalendronate sodium and cholecalciferolThis formula combines the original active ingredient in Fosamax plus vitamin D.

Signs of an allergic reactionlike rashhivesitchingredswollenblisteredor peeling skin with or without feverwheezingtightness in the chest or throattrouble breathingswallowingor talkingunusual hoarsenessor swelling of the mouthfacelipstongueor throatSigns of low calcium levels like muscle cramps or spasmsnumbness and tinglingor seizuresBlacktarryor bloody stoolsChest painCoughing up bloodVery bad belly painHeartburnTrouble swallowingVery bad pain when swallowingSore throatVery upset stomach or throwing upThrowing up blood or throw up that looks like coffee groundsVery bad bonejointor muscle painAny new or strange groinhipor thigh painMouth soresThis medicine may cause jawbone problemsThe chance may be higher the longer you take Fosamaxalendronate oral solutionThe chance may be higher if you have cancerdental problemsdentures that do not fit wellanemiablood clotting problemsor an infectionThe chance may also be higher if you are having dental workgetting chemo or radiationor taking other drugs that may cause jawbone problems like some steroid drugsThere are many drugs that can do thisAsk your doctor or pharmacist if you are not sureCall your doctor right away if you have jaw swelling or pain.

Use Fosamaxalendronate oral solutionas ordered by your doctorRead all information given to youFollow all instructions closely.

Measure liquid medicine with the dosing syringe providedor with a special dose-measuring spoon or medicine cupIf you do not have a dose-measuring deviceask your pharmacist for one.

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27Famularo GDe Simone CFatal esophageal perforation with alendronateAm J Gastroenterol 9620013212-3.

4Product InformationFosamaxalendronateMerckCoIncWest PointPA.

Rareless than 0.1Esophageal strictureoropharyngeal ulcerationupper gastrointestinal PUBperforationulcersbleeding)

Once-per-week dosingIf you forget to take Fosamax on your scheduled daytake it first thing in the morning on the day after you remember the missed doseThen return to your regular weekly schedule on your chosen dose dayDo not take 2 doses in one day.

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