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Some studies also link the drug to a small risk of esophageal cancerthough the FDA has not issued a warning.

Some side effects of alendronate may occur that usually do not need medical attentionThese side effects may go away during treatment as your body adjusts to the medicineAlsoyour health care professional may be able to tell you about ways to prevent or reduce some of these side effectsCheck with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Tell your doctor right away if you have any serious side effectsincludingjaw/ear painincreased or severe bone/joint/muscle painnew or unusual hip/thigh/groin painswelling of joints/hands/ankles/feetblack/tarry stoolsvomit that looks like coffee grounds.

Although an oral solution of alendronate may be available in the marketplaceFOSAMAX oral solution is no longer marketed.

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If a once-weekly dose of FOSAMAX is missedinstruct patients to take one dose on the morning after they rememberThey should not take two doses on the same day but should return to taking one dose once a weekas originally scheduled on their chosen day

CommentsRetreatment may be consideredfollowing a sixmonth post-treatment evaluation period in patients who have relapsedbased on increases in serum alkaline phosphatase measured periodicallyRetreatment may also be considered in patients who failed to normalize serum alkaline phosphatase.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effectsMany people using this medication do not have serious side effects.

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This medication works by slowing bone lossThis effect helps maintain strong bones and reduce the risk of broken bonesfracturesAlendronate belongs to a class of drugs called bisphosphonates.

WARNING/CAUTIONEven though it may be raresome people may have very bad and sometimes deadly side effects when taking a drugTell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

22Yue QYMortimer OAlendronateRisk for esophageal strictureJ Am Geriat Soc 4619981581-2.

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