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EVISTA should not be used for the primary or secondary prevention of cardiovascular diseaseIn a clinical trial of postmenopausal women with documented coronary heart disease or at increased risk for coronary eventsno cardiovascular benefit was demonstrated after treatment with raloxifene for 5 yearssee Clinical Studies
Tamoxifen-Controlled Trial Of Postmenopausal Women At Increased Risk For Invasive Breast CancerSTAR)
OsteoporosisEVISTA treats and prevents osteoporosis by helping make your bones stronger and less likely to breakInvasive Breast CancerIf you have osteoporosis or are at high risk for breast cancerEVISTA can be used to lower your chance of getting invasive breast cancerEVISTA will not totally get rid of your chance of getting breast cancerYour doctor can estimate your risk of breast cancer by asking you about risk factorsincludingyour agegetting olderfamily history of breast cancer in your mothersisteror daughtera history of any breast biopsyespecially an abnormal biopsy.
Raloxifene increases serum levels of high-density lipoprotein and apolipoprotein A-I and decreases levels of total cholesterollow-density lipoproteinfibrinogenapolipoprotein B and lipoproteinaIt does not appear to alter C-reactive protein levels.
Raloxifene is an estrogen agonist/antagonistcommonly referred to as a selective estrogen receptor modulatorSERMThe biological actions of raloxifene are largely mediated through binding to estrogen receptorsThis binding results in activation of estrogenic pathways in some tissuesagonismand blockade of estrogenic pathways in othersantagonismThe agonistic or antagonistic action of raloxifene depends on the extent of recruitment of coactivators and corepressors to estrogen receptorERtarget gene promoters.
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