However, taro-etodolac clearance is dependent on liver function and could be reduced in patients with severe hepatic failure.

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Etodolac is a weakly acidic drughaving a pKa of 4.65and its solubility is known to increase rapidly with pH values above the pKa of the drugHerzfeldi and Kummel1983

Lodine SR Tablets are for oral administrationEach tablet is capsularoval shaped light grey film coatedimpressed on one side with Lodine SR600 and contains etodolac 600mg in a sustained release formulation.

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lodine, etova is contraindicated in patients with hypersensitivity to etodolac.

The metabolites include 6-, 7-, and 8-hydroxylated-etodolac and etodolac glucuronide.

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Oedemahypertension and cardiac failurehave been reported in association with NSAID treatmentClinical trial and epidemiological data suggest that use of some NSAIDsparticularly at high doses and in long term treatmentmay be associated with an increased risk of arterial thrombotic eventsfor example myocardial infarction or strokesee section 4.4

The clinical benefit of preferential COX-2 inhibition over COX-1 has yet to be proven.

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