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Hepatotoxicity may occurif symptoms occurmeasure LFTs and discontinue drug.

Do not use these drugs with doxycyclineDoing so can cause dangerous effects in your bodyExamples of these drugs include:

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If Clostridium difficile associated diarrhea suspected or confirmedmay need to discontinue ongoing antibacterial use not directed against Cdifficilemay also need to institute appropriate fluid and electrolyte managementprotein supplementationantibacterial treatment of Cdifficileand surgical evaluation as clinically indicated.

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For children who weigh less than 99 pounds45 kgand have severe or life-threatening infection such as Rocky Mountain spotted feverThe recommended dosage is 2.2 mg/kg every 12 hoursFor children who weigh less than 99 pounds45 kgare older than 8 yearsand have less severe infectionThe recommended dosage on the first day of treatment is 4.4 mg/kgdivided into two dosesAfter thatthe daily maintenance dosage should be 2.2 mg/kggiven as a single dose or divided into two daily dosesFor children weighing 99 pounds45 kgor moreUse adult dosage.

Typical dosage2.4 mg/kg once dailyup to the adult doseBegin therapy 1 to 2 days before travel to the area with malariaContinue daily treatment for 4 weeks after leaving the area.

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