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Since cabergoline is extensively metabolized by the livercaution should be usedand careful monitoring exercisedwhen administering DOSTINEX to patients with hepatic impairment.

DOSTINEX Tablets are whitescoredcapsule-shaped tablets containing 0.5 mg cabergolineEach tablet is scored on one side and has the letter P and the letter U on either side of the breaklineThe other side of the tablet is engraved with the number 700.

When dispensing new prescriptions for these medicinesplease supply them in a new bottle with a child-resistant cap.

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Heartlungand kidney functionYour doctor will assess the functioning of your heartlungsand kidney if prolonged treatment is required as prolonged use of this medication can cause fibrosis or dysfunction of these organsIf you experience shortness of breatha cough that won’t go awayor chest paincontact your doctor as soon as possible.

Behaviour changesSome people have reported changes in behaviour associated with taking cabergolineThere have been occasional reports of aggressive behaviour or hostilityanxiousnessdisorientationor decreased memoryThis may be more likely to happen if you have a history of mental illnesssuch as depression or psychotic episodesIf you experience any of these effects or notice them in a family member who is taking this medicationcontact your doctor as soon as possible.

Before you begin using a medicationbe sure to inform your doctor of any medical conditions or allergies you may haveany medications you are takingwhether you are pregnant or breast-feedingand any other significant facts about your healthThese factors may affect how you should use this medication.

Following single oral doses of 0.5 mg to 1.5 mg given to 12 healthy adult volunteersmean peak plasma levels of 30 to 70 picogramspgmL of cabergoline were observed within 2 to 3 hoursOver the 0.5-to-7 mg dose rangecabergoline plasma levels appeared to be dose-proportional in 12 healthy adult volunteers and nine adult parkinsonian patientsA repeat-dose study in 12 healthy volunteers suggests that steady-state levels following a once-weekly dosing schedule are expected to be twofold to threefold higher than after a single doseThe absolute bioavailability of cabergoline is unknownA significant fraction of the administered dose undergoes a first-pass effectThe elimination half-life of cabergoline estimated from urinary data of 12 healthy subjects ranged between 63 to 69 hoursThe prolonged prolactin-lowering effect of cabergoline may be related to its slow elimination and long half-life.

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