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ADT is a corticosteroid dosing regimen in which twice the usual daily dose of corticoid is administered every other morningThe purpose of this mode of therapy is to provide the patient requiring long-term pharmacologic dose treatment with the beneficial effects of corticoids while minimizing certain undesirable effectsincluding pituitary-adrenal suppressionthe Cushingoid statecorticoid withdrawal symptomsand growth suppression in children.

The rationale for this treatment schedule is based on two major premisesathe anti-inflammatory or therapeutic effect of corticoids persists longer than their physical presence and metabolic effects andbadministration of the corticosteroid every other morning allows for re-establishment of more nearly normal hypothalamic-pituitary-adrenalHPAactivity on the off-steroid day.

5As indicated abovecertain corticosteroidsbecause of their prolonged suppressive effect on adrenal activityare not recommended for alternate day therapyegdexamethasone and betamethasone

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Tell your doctor before starting piroxicam if you take any of the following medicines anticoagulants blood thinners such as warfarin coumadin, jantoven aspirin other nsaids such as ibuprofen advil, motrin and naproxen aleve, naprosyn oral steroids such as dexamethasone decadron, dexone , methylprednisolone medrol , and prednisone deltasone .

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This medication may rarely make your blood sugar risewhich can cause or worsen diabetesTell your doctor right away if you have symptoms of high blood sugar such as increased thirst/urinationIf you already have diabetescheck your blood sugar regularly as directed and share the results with your doctorYour doctor may need to adjust your diabetes medicationexercise programor diet.

During pregnancythis medication should be used only when clearly neededIt may rarely harm an unborn babyDiscuss the risks and benefits with your doctorInfants born to mothers who have been using this medication for an extended period of time may have hormone problemsTell your doctor right away if you notice symptoms such as persistent nausea/vomitingsevere diarrheaor weakness in your newborn.

This medicine may cause stomach bleedingDaily use of alcohol while using this medicine may increase your risk for stomach bleedingLimit alcoholic beveragesConsult your doctor or pharmacist for more information.

Take prednisone exactly as prescribedThis medication comes in tablet and oral solution forms and is usually taken one to four times a day or every other daywith food or milkIf prednisone upsets your stomachyou should take the medication along with food or milkIf you miss a doseconsult your doctor or pharmacist to determine the appropriate course of treatmentDo not take two doses of prednisone at the same time.

Before using this medicationtell your doctor or pharmacist your medical historyespecially ofcurrent/past infectionssuch as fungal infectionstuberculosisherpesheart problemssuch as heart failurerecent heart attackhigh blood pressurethyroid problemskidney diseaseliver diseasestomach/intestinal problemssuch as ulcerdiverticulitisbone lossosteoporosismental/mood disorderssuch as psychosisanxietydepressioneye diseasessuch as cataractsglaucomadiabetesmineral imbalancesuch as low level of potassium/calcium in the bloodseizuresblood clotsbleeding problems.

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generic for deltasone prednisone prednisolone is a corticosteroid drug used to treat different conditions such as allergic disorders, immune system diseases, chronic obstructive pulmonary disease, psoriasis, skin problems, ulcerative colitis, spinal cord injuries, eye problems, arthritis, lupus, organ transplantation, and addison s disease.

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9Although many of the undesirable features of corticosteroid therapy can be minimized by ADTas in any therapeutic situationthe physician must carefully weigh the benefit-risk ratio for each patient in whom corticoid therapy is being considered.

How is this drug usedPrednisone is FDA approved for the treatment of leukemias and lymphomas in adults and acute leukemia of childhoodIt is also indicated for hypercalcemiahigh levels of calcium in the bloodassociated with cancer and mycosis fungoidesPrednisone may also be used to help prevent or reduce nausea and vomitingor to reduce the swelling surrounding cancerous tumors to relieve pressure caused by the swellingIt is important for patients to remember that physicians have the ability to prescribe medication for conditions other than those for which the drug has been approved by the FDAPatients who have received a prescription of this drug for a condition other than which it is approved may wish to discuss this issue with their physicianWhat is the mechanism of actionPrednisone belongs to a class of drugs called glucocorticoidsPrednisone produces its anti-cancer effects by inhibiting inflammatory agents in the bodywhich have been implicated in the development or growth of some cancers.

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7In using ADT it is importantas in all therapeutic situations to individualize and tailor the therapy to each patientComplete control of symptoms will not be possible in all patientsAn explanation of the benefits of ADT will help the patient to understand and tolerate the possible flare-up in symptoms which may occur in the latter part of the off-steroid dayOther symptomatic therapy may be added or increased at this time if needed.

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