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Some side effects may require medical attentionOther side effects do not require medical attention and may go away during treatmentPatients should check with their physician about any side effects that continue or are bothersome.

The adverse effects of corticosteroids in pediatric patients are similar to those in adultssee ADVERSE REACTIONSLike adultspediatric patients should be carefully observed with frequent measurements of blood pressureweightheightintraocular pressureand clinical evaluation for the presence of infectionpsychosocial disturbancesthromboembolismpeptic ulcerscataractsand osteoporosisPediatric patients who are treated with corticosteroids by any routeincluding systemically administered corticosteroidsmay experience a decrease in their growth velocityThis negative impact of corticosteroids on growth has been observed at low systemic doses and in the absence of laboratory evidence of hypothalamic-pituitary-adrenalHPAaxis suppressioni.ecosyntropin stimulation and basal cortisol plasma levelsGrowth velocity may therefore be a more sensitive indicator of systemic corticosteroid exposure in pediatric patients than some commonly used tests of HPA axis functionThe linear growth of pediatric patients treated with corticosteroids should be monitoredand the potential growth effects of prolonged treatment should be weighed against clinical benefits obtained and the availability of treatment alternativesIn order to minimize the potential growth effects of corticosteroidspediatric patients should be titrated to the lowest effective dose.

Since complications of treatment with corticosteroids are dependent on the size of the dose and the duration of treatmenta risk/benefit decision must be made in each individual case as to dose and duration of treatment and as to whether daily or intermittent therapy should be used.

Use lowest possible dose to control condition under treatmentrisk/benefit decision must be made in each individual case as to dose and duration of treatment and as to whether daily or intermittent therapy should be used.

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Average and large doses of corticosteroids can cause elevation of blood pressuresodium and water retentionand increased excretion of potassiumthese effects are less likely to occur with synthetic derivatives except when used in large dosesdietary salt restriction and potassium supplementation may be necessaryall corticosteroids increase calcium excretion.

IT SHOULD BE EMPHASIZED THAT DOSAGE REQUIREMENTS ARE VARIABLE AND MUST BE INDIVIDUALIZED ON THE BASIS OF THE DISEASE UNDER TREATMENT AND THE RESPONSE OF THE PATIENT.

Aspirin or similar medicinesPhenytoinEphedrinea nasal decongestantBarbituratesAntibiotics called rifampicin and rifabutinused to treat tuberculosisAnticoagulant medicines which thin the bloodMedicines for diabetesCertain diureticswater tabletsA medicine called carbamazepineused to treat epilepsypain and manic depressionAn anticancer medicine called aminoglutethimide.

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Diagnostic testing of adrenocortical hyperfunctiontrichinosis with neurologic or myocardial involvementtuberculous meningitis with subarachnoid block or impending block when used with appropriate antituberculous chemotherapy.

Patients should be warned not to discontinue the use of corticosteroids abruptly or without medical supervisionAs prolonged use may cause adrenal insufficiency and make patients dependent on corticosteroidsthey should advise any medical attendants that they are taking corticosteroids and they should seek medical advice at once should they develop an acute illness including fever or other signs of infectionFollowing prolonged therapywithdrawal of corticosteroids may result in symptoms of the corticosteroid withdrawal syndrome includingmyalgiaarthralgiaand malaise.

In the treatment of acute exacerbations of multiple sclerosisdaily doses of 30 mg of dexamethasone for a week followed by 4 to 12 mg every other day for one month have been shown to be effectivesee PRECAUTIONSNeuro-Psychiatric

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