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Kidney stones are a global affliction causing a great deal of morbidity and economic loss1 The prevalence of nephrolithiasis increases as societies become industrialized2,3,4 Thereforethe worldwide burden is likely to increase in future yearsA method to prevent kidney stones would be an obvious benefitExisting treatments with evidence that supports their long term efficacy to prevent calcium oxalate kidney stones include dietary and lifestyle changesas well as chronic use of one of three medicationsthiazidespotassium citrateand allopurinolNo new treatments have been established in decadesand these that are available have inherent problems related to patient compliancecosteffectiveness and side effectsThereforea preventive treatment that would be easy to takelow in costsafe and effective would be highly desirable.

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BenefitsCystone helps to flush the urinary tract safely and gentlyCystone maintains normal urine compositionCystone promotes normal kidney healthCystone promotes normal urinary tract healthCystone soothes the urinary tract using systemic flushingCystone supports normal equilibrium of pHacidity or alkalinein the bladderHelps in supporting the immune system.

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Small CaltropsGokshurais helpful the management of uro-genital diseases like kidney stonesbladder infection and other urinary tract infectionsIt helps promote general urinary tract health by eliminating dysuriapainful urination or blood present in urineand crystalluriaSmall Caltrops prevents the depositionaccumulation and supersaturation of calculogenic chemicals in urineIt is a potent antimicrobial agent.

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Small CaltropsGokshurais helpful the management of uro-genital diseases like kidney stonesbladder infection and other urinary tract infectionsIt helps promote general urinary tract health by eliminating dysuriapainful urination or blood present in urineand crystalluriaSmall Caltrops prevents the depositionaccumulation and supersaturation of calculogenic chemicals in urineIt is a potent antimicrobial agent.

Current treatments for stone prevention typically decrease urinary supersaturation by affecting urinary compositione.gdecrease calcium excretionNo agent is known that can be safely taken and enter the urine to decrease calcium oxalate crystallizationor perhaps even better dissolve calcium oxalate stones and/or crystalsIf such a compound were foundit would represent a new class of treatment for renal stonesSeveral herbs have been purported to decrease stone riskor hasten stone passageHoweverhard scientific evidence regarding their efficacy is scantyThe Chinese Kampou medicine has been used to treat disease for centuriesincluding for prevention and treatment of urinary calculiAn experimental study suggested an inhibitory effect of Kampou extracts on in vitro CaOx crystallization10 In this reportthe two species from KampouTakusya and Kagosoualso were effective for preventing renal crystallization in a rat nephrolithiasis modelsimilar results were obtained in a second report11 Chorey-toanother Chinese medicine which contains Takusyaalso exhibited a protective effect in rats rendered hyperoxaluric with ethylene glycoleven though urinary citrate levels fell12.

Ten patients4 men6 womenwith recurrentanalytically confirmedcalcium-containing kidney stones were recruited from the Mayo Stone ClinicAll were Caucasian adults and had passed at least one stone at entry into the studyTable 1Metabolic activity prior to study entry was defined as an increase in stone size or number documented on a previous CT scan obtained within one year prior to study entryOnly two patients were metabolically active at entry into the studyExclusions included age under 18 yearspregnancyrefusal to use an effective method of birth control during the studychronic urinary infectionsecondary causes of kidney stonese.gbowel diseaserenal tubular acidosisprimary hyperoxaluriaor mental incompetence to give informed written consent on a form approved by the institutional review boardAll patients were allowed to continue their existing kidney stone treatment programsAll patients promptly began the study after consenting to be enrolled.

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