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As with any antihypertensive agentsexcessive blood pressure decrease in patients with ischaemic cardiovascular and cerebrovascular disease could result in a myocardial infarction or stroke.

Although losartan may be used to prevent kidney problems or treat people who have kidney problemsit may also rarely cause serious kidney problems or make them worseYour doctor will check your kidney function while you are taking losartanTell your doctor right away if you have any signs of kidney problems such as a change in the amount of urine.

Dizziness or lightheadedness may occur as your body adjusts to the medicationIf any of these effects persist or worsentell your doctor or pharmacist promptly.

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Take Cozaar exactly as prescribed by your doctorFollow all directions on your prescription labelYour doctor may occasionally change your dose to make sure you get the best resultsDo not take this medicine in larger or smaller amounts or for longer than recommended.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effectsMany people using this medication do not have serious side effects.

Before taking losartantell your doctor or pharmacist if you are allergic to itor if you have any other allergiesThis product may contain inactive ingredientswhich can cause allergic reactions or other problemsTalk to your pharmacist for more details.

Numerous antihypertensive drugsfrom a variety of pharmacologic classes and with different mechanisms of actionhave been shown in randomized controlled trials to reduce cardiovascular morbidity and mortalityand it can be concluded that it is blood pressure reductionand not some other pharmacologic property of the drugsthat is largely responsible for those benefitsThe largest and most consistent cardiovascular outcome benefit has been a reduction in the risk of strokebut reductions in myocardial infarction and cardiovascular mortality also have been seen regularly.

Clinical trial data have shown that dual blockade of the renin-angiotensin-aldosterone systemRAASthrough the combined use of ACE-inhibitorsangiotensin II receptor blockers or aliskiren is associated with a higher frequency of adverse events such as hypotensionhyperkalaemiaand decreased renal functionincluding acute renal failurecompared to the use of a single RAAS-acting agentsee sections 4.34.4and 5.1

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Dizziness or lightheadedness may occur as your body adjusts to the medicationIf any of these effects persist or worsentell your doctor or pharmacist promptly.

Losartan is used to treat high blood pressurehypertensionand to help protect the kidneys from damage due to diabetesIt is also used to lower the risk of strokes in patients with high blood pressure and an enlarged heartLowering high blood pressure helps prevent strokesheart attacksand kidney problemsLosartan belongs to a class of drugs called angiotensin receptor blockersARBsIt works by relaxing blood vessels so that blood can flow more easily.

In elderly hypertensive patients the plasma concentrations of losartan and its active metabolite do not differ essentially from those found in young hypertensive patients.

Renal function should be regularly monitored during treatment with losartan as it may deteriorateThis applies particularly when losartan is given in the presence of other conditionsfeverdehydrationlikely to impair renal function.

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