Types of drugs that are known to interact with paroxetine include monoamine oxidase inhibitors maois , including isocarboxazid marplan , linezolid zyvox , and phenelzine nardil blood thinners, such as warfarin coumadin medications for irregular heartbeat, such as amiodarone cordarone, pacerone , encainide enkaid , and flecainide tambocor drugs used to treat nausea medications for migraine headaches, such as almotriptan axert , eletriptan relpax , and frovatriptan frova anti-seizure drugs, including phenobarbital and phenytoin dilantin antidepressants, such as amitriptyline elavil , amoxapine asendin , and clomipramine anafranil antihistamines aspirin and non-steroidal anti-inflammatory drugs nsaids , such as celecoxib celebrex , ibuprofen advil, motrin and naproxen aleve, naprosyn diuretics water pills codeine, which is found in many cough and pain medications other ssris, such as citalopram celexa , fluoxetine prozac, sarafem , and fluvoxamine luvox gastrointestinal drugs, including ranitidine zantac , metoclopramide reglan , and cimetidine tagamet certain antibiotics, such as rifampin rifadin, rimactane , isoniazid inh, nydrazid , and dicloxacillin dynapen the adhd drug atomoxetine straterra hiv drugs, including atazanavir reyataz and ritonavir norvir certain heart medications, such as clopidogrel plavix , metoprolol lopressor, toprol xl , and propranolol inderal anti-anxiety drugs, including buspirone buspar and diazepam valium drugs prescribed for other mental illnesses other than depression, including chlorpromazine thorazine , risperidone risperdal , and haloperidol haldol anti-fungal medications such as terbinafine lamisil certain pain medications, including fentanyl actiq, duragesic, fentora , meperidine demerol , and methadone dolophine the breast cancer drug tamoxifen nolvadex .
Information about Coumadin.
Frequency not reportedUnexplained decrease in hematocrithemoglobin decreasedRef]
For patients with a bileaflet mechanical valve or a Medtronic HallMinneapolisMNtilting disk valve in the aortic position who are in sinus rhythm and without left atrial enlargementtherapy with warfarin to a target INR of 2.5range2.0-3.0is recommendedFor patients with tilting disk valves and bileaflet mechanical valves in the mitral positiontherapy with warfarin to a target INR of 3.0range2.5-3.5is recommendedFor patients with caged ball or caged disk valvestherapy with warfarin to a target INR of 3.0range2.5-3.5is recommendedFor patients with a bioprosthetic valve in the mitral positiontherapy with warfarin to a target INR of 2.5range2.0-3.0for the first 3 months after valve insertion is recommendedIf additional risk factors for thromboembolism are presentAFprevious thromboembolismleft ventricular dysfunctiona target INR of 2.5range2.0-3.0is recommended.
VKORC1 and CYP2C9 gene variants generally explain the largest proportion of known variability in warfarin dose requirements.
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most discussions of drug benefits revolve around statistically concocted benefits of the drug, often in hand-picked patient populations, as is the case with coumadin stroke benefit studies.