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Sometimes in real life the cure rates can be lower than they are in clinical trials.

Your nursedoctor or pharmacist can tell you more about availability and coverage of ribavirin in your region.

If you are in one of the groups listed under special populationsspeak to your doctor about the most appropriate treatment options.

Ribavirin is not effective when used alone to treat hepatitis CIt must be used together with an interferon alfa productsuch as Peg-Intron or Intron Ato treat chronic hepatitis C.

The HIV medicationsAZTzidovudineRetrovirand also found in the combination pills Combivir and Trizivirlamivudine3TCstavudined4TZeritthe medication to lower immune response or prevent organ transplant failureazathioprine.

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Severe liver diseaseespecially cirrhosisautoimmune hepatitisa hemoglobin disorder such as anemiathalassemiaMediterranean anemiaor sickle-cell anemiaif you are also taking didanosineVidexor if you are pregnant womanor a man whose female sexual partner is pregnant.

It is not known whether ribavirin passes into breast milk or if it could harm a nursing babyYou should not breast-feed while you are taking ribavirin.

Tell your doctor right away if a pregnancy occurs while either the mother or the father is taking ribavirin.

Problems with your visionfeverchillsbody achesflu symptomssevere pain in your upper stomach spreading to your backnausea and vomitingfast heart ratestabbing chest painwheezingfeeling short of breathsevere depressionhallucinationsthoughts of suicide or hurting yourselfchest pain or heavy feelingpain spreading to the arm or shouldernauseasweatinggeneral ill feelingor pale or yellowed skindark colored urineeasy bruising or bleedingconfusionor unusual weakness.

Rednesssorenessor other reactions at the site of injectionpeginterferonwhich is taken with ribavirinis an injected medicationFatigue or tiredness Headache Fever or chills Nausea Muscle aches Anxiety or emotional irritability 1,2.

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Ribavirin must be taken in combination with other medications such as Harvonisofosbuvir or Zepatierso all of the warnings that apply to the other medications also apply to people considering ribavirinFor more information on hepatitis C medicationssee the drug fact sheets.

4McHutchinson J.GGordon S.CSchiff E.Ret alInterferon alfa 2b alone or in combination with ribavirin as initial treatment for chronic hepatitis CNEnglJMed 1998339:1485-92Links

The daily dose of COPEGUS is 800 mg to 1200 mg administered orally in two divided dosesThe dose should be individualized to the patient depending on baseline disease characteristicse.ggenotyperesponse to therapyand tolerability of the regimen.

Copegus is indicated in combination with Pegasys or Roferon A for the treatment of adult patients with chronic hepatitis C who have not previously been treatedincluding patients with fibrosis or compensated cirrhosisIt is also indicated for the treatment of adult patients who have responded to interferon alpha monotherapy but have since relapsed.

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