Metabolism of colchicine in vivo has not been fully investigated in humans niel and scherrmann, 2006 , but the in vitro experiments have demonstrated that colchicine undergoes same oxidative demethylation in both human and rat liver microsomes tateishi et al.

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Toxic manifestations associated with colchicine include myelosuppressiondisseminated intravascular coagulationand injury to cells in the renalhepaticcirculatoryand central nervous systemThese most often occur with excessive accumulation or overdosagesee OVERDOSE

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

About all of your medical conditions if you have kidney or liver problems if you are pregnant or plan to become pregnantIt is not known if colchicine capsules can harm your unborn babyTalk to your healthcare provider if you are pregnant or plan to become pregnantif you are breastfeeding or plan to breastfeedColchicine can pass into your breast milk and may harm your babyTalk to your healthcare provider about the best way to feed your baby if you take colchicine capsules.

If co-administration of colchicine capsules and a CYP3A4 inhibitor is necessarythe dose of colchicine capsules should be adjusted by either reducing the daily dose or reducing the dose frequencyand the patient should be monitored carefully for colchicine toxicitySee CLINICAL PHARMACOLOGY

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This Medication Guide has been approved by the U.SFood and Drug Administration.

The dosage is based on your medical conditionother drugs/foods you may be takingand response to treatmentTo reduce your risk for serious side effectsdo not increase your dosetake it more frequentlyor take it for a longer time than directed by your doctorSerious side effects may occur even at usual prescribed doses.

Patients with both renal and hepatic impairment should not be given colchicine capsules.

Co-administration of colchicine capsules with propafenonea P-gp inhibitorat 225 mg BID for 5 daysin a pharmacokinetic study in healthy volunteersdid not cause any changes in systemic levels of colchicineThis indicates that propafenone can be administered with colchicine capsules without any dose adjustmentHoweverthese results should not be extrapolated to other P-gp inhibitors as colchicine is known to be a substrate for P-gp and case reports of colchicine toxicity associated with the co-administration of P-gp inhibitors such as cyclosporine have been published.

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cases of myopathy, including rhabdomyolysis, have been reported with atorvastatinco-administered with colchicine, and caution should be exercised when prescribing atorvastatin with colchicine see drug interactions .

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While colchicine may reduce risk of a second cv event in the general population, there is limited research on how colchicine may be used for control, treatment, or prevention.

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Effects of short-term less than 8-hours exposure the first phase of colchicine toxicity consists of gastrointestinal symptoms burning sensation in the throat, nausea, vomiting, diarrhea, and abdominal pain.

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In their response to criticism, fda officials have noted that colchicine had been associated with 117 non-overdose deaths, half of them involving an interaction between colchicine and the antibiotic clarithromycin.

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regardless of the absolute primacy of the cytoskeleton or some other molecule in the sensation and relay of pressure-derived signals, microtubule disruption by colchicine appears sufficient to inhibit pressure-mediated functional effects on cell adhesion.

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