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Neonates exposed to Celexa and other SSRIs or SNRIslate in the third trimesterhave developed complications requiring prolonged hospitalizationrespiratory supportand tube feedingsee PRECAUTIONSWhen treating pregnant women with Celexa during the third trimesterthe physician should carefully consider the potential risks and benefits of treatment.

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Individually corrected QTcQTcNiinterval was evaluated in a randomizedplacebo and activemoxifloxacin 400 mgcontrolled cross-overescalating multiple-dose study in 119 healthy subjectsThe maximum meanupper bound of the 95one-sided confidence intervaldifference from placebo were 8.510.8and 18.521.0msec for 20 mg and 60 mg citalopramrespectivelyBased on the established exposure-response relationshipthe predicted QTcNi change from placeboupper bound of the 95one-sided confidence intervalunder the Cmax for the dose of 40 mg is 12.614.3msec.

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In animal reproduction studiescitalopram has been shown to have adverse effects on embryo/fetal and postnatal developmentincluding teratogenic effectswhen administered at doses greater than human therapeutic doses.

SSRIs and SNRIsincluding Celexahave been associated with cases of clinically significant hyponatremia in elderly patientswho may be at greater risk for this adverse eventsee PRECAUTIONSHyponatremia

The antidepressant action of Celexa in hospitalized depressed patients has not been adequately studied.

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