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Cases of death or hospitalization due to severe liver injuryhepatic failurehave been reported postmarketing in association with the use of CasodexHepatotoxicity in these reports generally occurred within the first three to four months of treatmentHepatitis or marked increases in liver enzymes leading to drug discontinuation occurred in approximately 1of Casodex patients in controlled clinical trials.

Casodex may have an effect on male fertility which could be reversibleTalk to your healthcare provider if this is a concern for you.

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In vitro protein binding studies have shown that bicalutamide can displace coumarin anticoagulants from binding sitesPT/INR should be closely monitored in patients concomitantly receiving coumarin anticoagulants and CasodexAdjustment of the anticoagulant dose may be necessarysee Warnings and Precautions5.2and Adverse Reactions6.2

Casodex 50 mg daily is indicated for use in combination therapy with a luteinizing hormone-releasing hormoneLHRHanalog for the treatment of Stage D 2 metastatic carcinoma of the prostate.

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Increased values in liver enzyme tests include increased ASTALTor bothThis effect has occurred in approximately 6of treated patientsRef]

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