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The safety and effectiveness of these medicines have not been established in children.

There are no well-controlled studies in pregnant womenthereforeuse CARDIZEM in pregnant women only if the potential benefit justifies the potential risk to the fetus.

Dizzinesslightheadednessweaknessnauseaflushingconstipationand headache may occurIf any of these effects persist or worsentell your doctor or pharmacist promptly.

Get up slowly when getting out of bed or standing up if you feel light-headeddizzy or faint.

Get emergency medical help if you have any of these signs of an allergic reactionhivesdifficulty breathingswelling of your facelipstongueor throat.

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Intravenous cardizem in doses of 20 mg prolongs ah conduction time and av node functional and effective refractory periods approximately 20 .

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Some products have ingredients that could raise your heart rate or worsen your chest painTell your pharmacist what products you are usingand ask how to use them safelyespecially cough-and-cold productsdiet aidsor NSAIDs such as ibuprofen/naproxen

Asthmawheezing or shortness of breath swelling of the facelips or tonguewhich may cause difficulty in swallowing or breathing hivesitching or skin rash fainting.

To make sure you can safely take diltiazemtell your doctor if you have any of these other conditions:

Angina is a pain or uncomfortable sensation in the chestoften spreading to the arms or neck and sometimes to the shoulders and backThe pain of angina is due to a shortage of oxygen to the heart.

To make sure you can safely take diltiazemtell your doctor if you have any of these other conditions:

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In a healthy volunteer cross-over studyN=10co-administration of a single 20 mg dose of simvastatin at the end of a 14 day regimen with 120 mg BID diltiazem SR resulted in a 5-fold increase in mean simvastatin AUC versus simvastatin aloneSubjects with increased average steady-state exposures of diltiazem showed a greater fold increase in simvastatin exposureComputer-based simulations showed that at a daily dose of 480 mg of diltiazeman 8-to 9-fold mean increase in simvastatin AUC can be expectedIf co-administration of simvastatin with diltiazem is requiredlimit the daily doses of simvastatin to 10 mg and diltiazem to 240 mg.

Due to the potential for additive effectscaution and careful titration are warranted in patients receiving CARDIZEM concomitantly with any agents known to affect cardiac contractility and/or conductionsee WARNINGS

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