When used for smoking cessation, bupropion zyban usually is started as 150 mg once daily for three days, and then the dose is increased to 150 mg twice daily for 7 to 12 weeks if the patient tolerates the starting dose.

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prasugrel in healthy subjects, prasugrel increased bupropion cmax and auc values by 14 and 18 , respectively, and decreased cmax and auc values of hydroxybupropion by 32 and 24 , respectively.

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, quinidine, bupropion, fluoxetine, and paroxetine see drug interactions 7.

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citalopram plus bupropion helped 30 percent of patients achieve remission, but it s not clear whether this effect is any greater than a placebo effect.

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the effect of hepatic impairment on the pharmacokinetics of bupropion was characterized in 2 single-dose studies, one in patients with alcoholic liver disease and one in patients with mild to severe cirrhosis.
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Aplenzin bupropion hydrobromide 174 mg po qday initially equivalent to 150 mg bupropion hcl ; after 1 week, may increase to usual target dose of 348 mg day equivalent to 300 mg bupropion hcl .

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A single-dose pharmacokinetic study demonstrated that the disposition of bupropion and its metabolites in elderly subjects was similar to that of younger subjects; however, another pharmacokinetic study, single and multiple dose, has suggested that the elderly are at increased risk for accumulation of bupropion and its metabolites see clinical pharmacology .

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additionally, in a study comparing 14-day dosing with wellbutrin xl tablets 300 mg once daily to the sustained-release formulation of bupropion at 150 mg 2 times daily, equivalence was demonstrated for peak plasma concentration and area under the curve for bupropion and the 3 metabolites.

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bupropion is metabolised to its major active metabolite hydroxybupropion primarily by the cytochrome p450 cyp2b6 see section 5.

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according to the manufacturer of wellbutrin, drinking excessive amounts or abruptly withdrawing from alcohol after chronic use may increase the risk of seizure event in patients taking bupropion.
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The results of the present study indicate that rats reliably self-administer both bupropion and nomifensine.

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