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Seizure risk is dose-relatedcan minimize risk by limiting daily dose to 522 mg and gradually increasing dosediscontinue permanently in patients who experience seizures.

Risk of mydriasismay trigger angle closure attack in patients with angle closure glaucoma with anatomically narrow angles without a patent iridectomyuse caution.

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A single-dose pharmacokinetic study demonstrated that the disposition of bupropion and its metabolites in elderly subjects was similar to that of younger subjects; however, another pharmacokinetic study, single and multiple dose, has suggested that the elderly are at increased risk for accumulation of bupropion and its metabolites see clinical pharmacology .

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