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If you take Zyban to help you stop smokingyou may continue to smoke for about 1 week after you start the medicineSet a date to quit smoking during the second week of treatmentTalk to your doctor if you are having trouble quitting after you have used Zyban for at least 7 weeks.
Wellbutrin XLRInitial150 mg orally once a day in the morning TitrationIf toleratedafter 7 days dose may be increased to maximum dose of 300 mg once a day administered in the morningPatients who are unable to tolerate this increase in dose should be reduced back to 150 mg orally once a day.
Steady-State Plasma Level Concentrations for Bupropion 300 mg/day for IRSRand XL Formulations a.
Early in the development of bupropion for the treatment of major depressive disorderit was observed that bupropion-treated patients appeared less likely to switch to mania5051 Based on these reportsa small desipramine-comparator study with bupropion was conducted in patients with bipolar I depressive episodes52 Bupropion was as effective as desipramine for bipolar depressionbut was associated with a statistically lower rate of switch into mania over a 1-year periodA subsequent report from the same group expanding the sample size of the original report confirmed the comparable efficacy in the treatment of bipolar depression between desipramine and bupropionbut the switch rate for bupropion was not significantly different from desipraminealthough there was a trend toward a lower rate for bupropion53 The use of bupropion in the treatment of bipolar depression has not been approved by the FDA.
Table 4Treatment Discontinuations Due to Adverse Events in Placebo-Controlled Trials.
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