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Frequency not reportedAbnormalities in mental statuspost-ictal confusionsleep disturbances.

Finallyit is important to emphasize that the tabulation does not reflect the relative severity and/or clinical importance of the eventsA better perspective on the serious adverse events associated with the use of bupropion is provided in the WARNINGS and PRECAUTIONS sections.

Two cases of elderly patients falling backwards have been attributed to the effects of bupropion on the basal gangliaRef]

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Report any new or worsening symptoms to your doctorsuch asmood or behavior changesanxietypanic attackstrouble sleepingor if you feel impulsiveirritableagitatedhostileaggressiverestlesshyperactivementally or physicallymore depressedor have thoughts about suicide or hurting yourself.

Commonly reported side effects of bupropion includeinsomnianauseapharyngitisweight lossconstipationdizzinessheadacheand xerostomiaOther side effects includeabdominal painagitationarthralgiachest painmigraineskin rashurinary frequencyanxietyastheniaconfusiondiarrheahostilityhypertensionlack of concentrationmyalgianervousnesspalpitationspruritustinnitustremorvomitinganorexiadiaphoresisdysgeusiaflushingand abnormal dreamsSee below for a comprehensive list of adverse effects.

Among antidepressantsbupropion may be associated with the lowest incidence of sexual dysfunctioni.eimpotenceabnormal ejaculationchanges in libidoRef]

There are also data regarding the use of bupropion for seasonal affective disorderThe initial report was a small open uncontrolled study43 Recently2 multicenter studies evaluating bupropion XL versus placebo for the prevention of seasonal depressive episodes were completeddata on fileGlaxoSmithKlineResearch Triangle ParkN.CIn the pooled analysis of both studiesbupropion XL was found to have a significant effect preventing the onset of a seasonal depressive episode.

Adverse Events Leading to Discontinuation of Treatment With the Immediate-Release or Sustained-Release Formulations of Bupropion.

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Findings in clinical trialshoweverare not known to reliably predict the abuse potential of drugsNonethelessevidence from single-dose studies does suggest that the recommended daily dosage of bupropion when administered in divided doses is not likely to be especially reinforcing to amphetamine or stimulant abusersHoweverhigher doses that could not be tested because of the risk of seizure might be modestly attractive to those who abuse stimulant drugs.

OBJECTIVEOn the basis of the clinical observations that bupropion facilitated weight losswe investigated the efficacy and tolerability of this drug in overweight and obese adult women.

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