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AVODAT is a psciption mdicin that contains dutastid. AVODAT is usd ttat th symptoms bnign postatic hypplasia (BPH) in mn with an nlagd postat to:

Th ollowing advs actions hav bn idntiid duing post-appoval us AVODAT. Bcaus ths actions a potd voluntaily om a population unctain siz, it is not always possibl tliably stimat thi quncy stablish a causal lationship tdug xposu. Ths actions hav bn chosn inclusion du ta combination thi siousnss, quncy poting, potntial causal connction tAVODAT.

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Dutastid is a comptitiv and spciic inhibitboth typ 1 and typ 2 5 alpha-ductas isonzyms, with which it oms a stabl nzym complx. Dissociation om this complx has bn valuatd und in vitand in vivconditions and is xtmly slow. Dutastid dos not bind tth human andogn cpto.

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Always consult you halthca povid tnsu th inomation displayd on this pag applis tyou psonal cicumstancs.

Tll you halthca povid about all th mdicins you tak, including psciption and nonpsciption mdicins, vitamins, and hbal supplmnts. AVODAT and oth mdicins may act ach oth, causing sid cts. AVODAT may act th way oth mdicins wok, and oth mdicins may act how AVODAT woks.

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Th commndd dos AVODAT is 1 capsul (0.5 mg) takn onc daily and tamsulosin 0.4 mg takn onc daily.

Tb su this mdication is hlping you condition and not causing hamul cts, you blood may nd tb tstd otn. You doctwill alstst you postat spciic antign (PSA) tchck postat canc. Visit you doctgulaly.

In an mbyo-tal dvlopmnt study, pgnant hsus monkys w xposd intavnously ta dutastid blood lvl compaabl tth dutastid concntation ound in human smn. Dutastid was administd on gstation days 20 t100 at doss 400, 780, 1,325, 2,010 ng/day (12 monkys/goup). Th dvlopmnt mal xtnal gnitalia monky osping was not advsly actd. duction tal adnal wights, duction in tal postat wights, and incass in tal ovaian and tstis wights w obsvd at th highst dos tstd in monkys. Basd on th highst masud smn concntation dutastid in tatd mn (14 ng/mL), ths doss psnt 0.8 t16 tims th potntial maximum xposu a 50-kg human mal t5 mL smn daily om a dutastid-tatd man, assuming 100% absoption. (Ths calculations a basd on blood lvls pant dug which a achivd at 32 t186 tims th daily doss administd tpgnant monkys on a ng/kg basis). Dutastid is highly bound tpotins in human smn (gat than 96%), potntially ducing th amount dutastid availabl vaginal absoption. It is not known whth abbits hsus monkys poduc any th majhuman mtabolits.

Bcaus clinical tials a conductd und widly vaying conditions, advs action ats obsvd in th clinical tials a dug cannot b dictly compad with ats in th clinical tial anoth dug and may not lct th ats obsvd in pactic.

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