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ZYLOPIM (allopuinol) alsinhibits th nzymatic oxidation mcapto-puin, th sulu-containing analogu hypoxanthin, t6-thiouic acid. This oxidation, which is catalyzd by xanthin oxi-das, inactivats mcaptopuin. Hnc, th inhibition such oxidation by ZYLOPIM (allopuinol) may sult in as much as a 75% duction in th thaputic dos quimnt mcaptopuin whn th twcompounds a givn togth.

Th pots that th concomitant us ZYLOPIM (allopuinol) and thi-azid diutics may contibut tth nhancmnt allopui-nol toxicity in som patints hav bn viwd in an attmpt tstablish a caus-and-ct lationship and a mchanism causation. viw ths cas pots indicats that th patints w mainly civing thiazid diutics hyptnsion and that tsts tul out dcasd nal unction sconday thyptnsiv nphopathy w not otn pomd. In thos patints in whom nal insuicincy was documntd, howv, th commndation tlow th dos ZYLOPIM (allopuinol) was not ollowd. Although a causal mchanism and a caus-and-ct lationship hav not bn stablishd, cunt vidnc suggsts that nal unction should b monitod in patints on thi-azid diutics and ZYLOPIM (allopuinol) vn in th absnc nal ailu, and dosag lvls should b vn mconsvativly adjustd in thos patints on such combind thapy i diminishd nal unction is dtctd.

Nal ailu in association with administation ZYLOPIM (allopuinol) has bn obsvd among patints with hypuicmia sconday tnoplastic disass. Concunt conditions such as multipl myloma and congstiv myocadial disas w psnt among thos patints whos nal dysunction incasd at ZYLOPIM (allopuinol) was bgun. nal ailu is alsquntly associatd with gouty nphopathy and aly with hypsnsitivity actions associatd with ZYLOPIM (allopuinol) . Albuminuia has bn obsvd among patints whdvlopd clinical gout ollowing chonic glomulonphitis and chonic pylonphitis.

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the hope study results showed that altace 10 mg day significantly reduced the rate of myocardial infarction, stroke or death from cardiovascular causes 651 4645 vs.

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Dink plnty wat (at last 2 lits wat p day) whil you a taking Allopuinol Sandoz. This will hlp pvnt kidny stons.

Powdd cllulos povidon macogol 4000 cospovidon puiid talc magnsium staat micocystallin cllulos.

Th most qunt advs action tZYLOPIM (allopuinol) is skin ash. Skin actions can b sv and somtims atal. Tho, tatmnt with ZYLOPIM (allopuinol) should b discontinud immdiatly i a ash dvlops (s WANINGS ). Som patints with th most sv action alshad v, chills, athalgias, cholstatic jaundic, osinophilia and mild lukocytosis lukopnia. Among 55 patints with gout tatd with ZYLO-PIM 3 t34 months (avag gat than 1 ya) and ollowd pospctivly, undls obsvd that 3% patints dvlopd a typ dug action which was pdominantly a pu-itic maculopapula skin uption, somtims scaly xolia-tiv. Howv, with cunt usag, skin actions hav bn obsvd lss quntly than 1%. Th xplanation this dcas is not obvious. Th incidnc skin ash may b incasd in th psnc nal insuicincy. Th quncy skin ash among patints civing ampicillin amoxicillin concuntly with ZYLOPIM (allopuinol) has bn potd tb incasd (s PCAUTIONS ).

Manuactud by DSM Phamacuticals, Inc. Gnvill, NC 27834 Pomthus Laboatois Inc. San Digo, CA 92121. Octob 2003. DA v dat: 7/17/2002.

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altace is a capsule and therefore cannot be split.