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Blurred vision or eye problemsfast heartbeatmood changeshallucinationsseeing or hearing thingsconfusionthoughts of hurting yourselfnauseastomach painlow feverloss of appetitedark urineclay-colored stoolsjaundiceyellowing of the skin or eyesear.
Get emergency medical help if you have any of these signs of an allergic reactionhivesdifficulty breathingswelling of your facelipstongueor throat.
Clinicians are reminded that there is no completely reliable method for determining whether a patient has had an adequate opioid-free periodA naloxone challenge test may be helpful if there is any question of occult opioid dependenceIf signs of opioid withdrawal are still observed following naloxone challengetreatment with REVIA should not be attemptedThe naloxone challenge can be repeated in 24 hours.
There are no systematically collected data that specifically address the switch from buprenorphine or methadone to REVIAhoweverreview of postmarketing case reports have indicated that some patients may experience severe manifestations of precipitated withdrawal when being switched from opioid agonist therapy to opioid antagonist therapysee WARNINGSPatients transitioning from buprenorphine or methadone may be vulnerable to precipitation of withdrawal symptoms for as long as 2 weeksHealthcare providers should be prepared to manage withdrawal symptomatically with non-opioid medications.
Allodynic TherapeuticsLLC1785 NE 123rd StreetNorth MiamiFL 33181-2537.
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the combination of naltrexone and disulfiram , a drug that is also used for alcohol abuse, may cause increased liver toxicity and liver damage when taken together.