Since a comparison was not made between prazosin patients on ssris and placebo patients on ssris, it cannot be determined whether this is a result of selection bias for treatment-resistant ptsd sufferers with severe ptsd required for study inclusion, or whether this represents evidence of an antagonistic effect of ssri treatment on the clinical benefits of prazosin.
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however, prazosin was shown to be more effective when treating nightmares related to ptsd.
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