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Complete pretreatment blood countsincluding platelets and possibly reticulocytes and serum ironshould be obtained as a baselineIf a patient in the course of treatment exhibits low or decreased white blood cell or platelet countsthe patient should be monitored closelyDiscontinuation of the drug should be considered if any evidence of significant bone marrow depression develops.
Do not drink alcohol or take other drugs that make you sleepy or dizzy while taking TEGRETOL until you talk to your healthcare providerTEGRETOL taken with alcoholor drugs that cause sleepiness or dizziness may make your sleepiness or dizziness worseDo not driveoperate heavy machineryor do other dangerous activities until you knowhow TEGRETOL affects youTEGRETOL may slow your thinking and motor skills.
Congestive heart failureedemaaggravation of hypertensionhypotensionsyncope and collapseaggravation of coronary artery diseasearrhythmias and AV blockthrombophlebitisthromboembolisme.gpulmonary embolismand adenopathy or lymphadenopathy.
Because of the relationship of the drug to other tricyclic compoundsthe possibility of activation of a latent psychosis andin elderly patientsof confusion or agitation should be borne in mind.
Prior to initiating Tegretol therapytesting for HLA-B*1502 should be performed in patients with ancestry in populations in which HLA-B*1502 may be presentIn deciding which patients to screenthe rates provided above for the prevalence of HLA-B*1502 may offer a rough guidekeeping in mind the limitations of these figures due to wide variability in rates even within ethnic groupsthe difficulty in ascertaining ethnic ancestryand the likelihood of mixed ancestryTegretol should not be used in patients positive for HLA-B*1502 unless the benefits clearly outweigh the risksTested patients who are found to be negative for the allele are thought to have a low risk of SJS/TENsee BOXED WARNING and PRECAUTIONSLaboratory Tests
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