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Concomitant treatment of ACE inhibitors with mammalian target of rapamycinmTORinhibitorse.gtemsirolimussirolimuseverolimusor neutral endopeptidaseNEPinhibitorse.gracecadotrilor tissue plasminogen activator may increase the risk of angioedema.
Thiazidesincluding hydrochlorothiazidecan cause fluid or electrolyte imbalancehypokalaemiahyponatraemiaand hypochloremic alkalosisWarning signs of fluid or electrolyte imbalance are dryness of mouththirstweaknesslethargydrowsinessmuscle pain or crampsmuscular fatiguehypotensionoliguriatachycardiaand gastrointestinal disturbances such as nausea or vomitingDilutional hyponatraemia may occur in oedematous patients in hot weatherChloride deficit is generally mild and does not require treatmentThiazides have been shown to increase the urinary excretions of magnesiumwhich may result in hypomagnesaemia.
Hypokalemia may develop during concomitant use of steroids or adrenocorticotropic hormoneACTH
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