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Kidney problems can sometimes occur with the use of NSAID medicationsincluding mefenamic acidProblems are more likely to occur if you are dehydratedhave heart failure or kidney diseaseare an older adultor if you take certain medicationssee also Drug Interactions sectionDrink plenty of fluids as directed by your doctor to prevent dehydration and tell your doctor right away if you have a change in the amount of urine.
This medication should not be used if you have certain medical conditionsBefore using this medicineconsult your doctor or pharmacist if you haveaspirin-sensitive asthmaa history of worsening breathing with runny/stuffy nose after taking aspirin or other NSAIDssevere kidney diseaserecent heart bypass surgeryCABGactive bleeding/sores in stomach/intestinesulcergastrointestinal bleeding
Advise patients to report symptoms of ulcerations and bleedingincluding epigastric paindyspepsiamelenaand hematemesis to their healthcare providerIn the setting of concomitant use of low-dose aspirin for cardiac prophylaxisinform patients of the increased risk for and the signs and symptoms of GI bleedingsee WARNINGSGastrointestinal BleedingUlcerationand Perforation
This medicine can increase your risk of life-threatening heart or circulation problemsincluding heart attack or strokeDo not use this medicine just before or after having heart bypass surgeryalso called coronary artery bypass graftor CABG
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